Medical Science

UPSC Medical Science 2025

All 16 questions from the 2025 Civil Services Mains Medical Science paper across 2 papers — 800 marks in total. Each question comes with a detailed evaluation rubric, directive word analysis, and model answer points.

16Questions
800Total marks
2Papers
2025Exam year

Paper I

8 questions · 400 marks
Q1
50M Compulsory describe Anatomy, Physiology and Pathology

(a) Describe the formation, course and branches of ulnar nerve. Which muscles do each of the branches supply ? Why is ulnar nerve called the "musician's nerve" ? 10 marks (b) Name…

Q2
50M trace Neurophysiology, Renal Physiology and Cardiovascular Physiology

(a) Using a well labelled diagram, trace the taste pathway from circumvallate papillae of tongue to the cerebral cortex. 15 marks (b)(i) Enumerate any five tests for the assessmen…

Q3
50M describe Pelvic anatomy, urethral injury, biochemistry, immunology

(a) A 36-year-old cyclist suffered pelvic injury while riding into a pothole on the road. Following this incident, he has severe pelvic pain and is unable to pass urine. His retro…

Q4
50M explain Breast cancer anatomy, knee ligaments, RIA, immunology

(a) (i) A 55-year-old lady visits surgery OPD with a three month old history of a painless hard swelling in her left breast. On examination, it is found that the swelling is firm,…

Q5
50M Compulsory enumerate Pharmacology, Pathology, Microbiology, Forensic Medicine

(a) (i) Enumerate the topical antifungal drugs along with their indication and side effects. 5 marks (ii) Name antihelminitic drugs used in treatment of neurocysticercosis and als…

Q6
50M describe Hematology, Pathology, Pharmacology, Microbiology, Infectious Diseases

(a) (i) Describe the approach to laboratory diagnosis of chronic myeloid leukemia – chronic phase. 10 marks (ii) Describe the gross and light microscopic changes evolved over two…

Q7
50M describe Forensic Medicine, Pathology and Pharmacology

(a) (i) Define 'drowning'. Enumerate the different modes of death in a case of drowning. List the postmortem findings in a case of wet drowning. 10 marks (ii) Describe Diatom Test…

Q8
50M describe Microbiology, Forensic Medicine and Pharmacology

(a) (i) Describe the challenges of circulating Vaccine-Derived Poliovirus (VDPV). Add a note on the environmental surveillance and preventive strategies for effective maintenance…

Paper II

8 questions · 400 marks
Q1
50M Compulsory discuss Preventive and social medicine, infectious diseases, malnutrition

(a) Briefly describe the role of lifestyle interventions in prevention of coronary artery disease. 10 (b) Discuss the role of various imaging modalities in the diagnostic evaluati…

Q2
50M outline Diabetic ketoacidosis, diarrhoea, dermatology

(a) A 23-year-old woman with type I diabetes mellitus presents with nausea, vomiting and altered sensorium. On examination, she is tachypneic and hypotensive. Her random blood sug…

Q3
50M elaborate Hepatitis B, neonatal respiratory distress, psoriasis in pregnancy

(a) (i) Elaborate the indications for initiating antiviral therapy in a patient with chronic hepatitis B. (ii) Write the first-line antivirus treatment regimen for the management…

Q4
50M differentiate Leukaemia, immunization, renovascular hypertension

(a) (i) How do you differentiate between acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) based on peripheral smear and bone marrow findings? (ii) Describe th…

Q5
50M Compulsory discuss Surgery, obstetrics and gynaecology, public health

(a) (i) Enumerate the advantages as well as the limitations of laparoscopic surgery. (ii) Describe the different techniques of creating pneumoperitoneum during laparoscopic surger…

Q6
50M discuss Obstetrics, gastroenterology, community health

(a) (i) Classify hypertensive disorders in pregnancy. (ii) Enumerate the types and complications of eclampsia. (iii) Discuss the management of antepartum eclampsia in a 25-year-ol…

Q7
50M describe General surgery, public health nutrition, reproductive medicine

(a) (i) Describe the clinical features and diagnostic workup of a suspected case of peritonitis. (ii) Enumerate the principles of management of peritonitis. (iii) Enlist the impor…

Q8
50M describe Malaria elimination, contraception, cleft palate

(a) Under the National Framework for Malaria Elimination in India, what are the targets set for the years 2027 and 2030 respectively? What are the key interventions recommended fo…

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